Antibody domain mutants demonstrate autonomy of the antigen binding site.
نویسندگان
چکیده
منابع مشابه
Structural Analyses of the Slm1-PH Domain Demonstrate Ligand Binding in the Non-Canonical Site
BACKGROUND Pleckstrin homology (PH) domains are common membrane-targeting modules and their best characterized ligands are a set of important signaling lipids that include phosphatidylinositol phosphates (PtdInsPs). PH domains recognize PtdInsPs through two distinct mechanisms that use different binding pockets on opposite sides of the β-strands 1 and 2: i) a canonical binding site delimited by...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1990
ISSN: 0261-4189
DOI: 10.1002/j.1460-2075.1990.tb08209.x